*eye KOY sa noid*
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(‘eicosanoids’ are ‘signaling molecules’ made by the ‘enzymatic’ or ‘non-enzymatic’ oxidation of ‘arachidonic acid’ or other ‘polyunsaturated fatty acids’ (‘PUFAs’) that are – (similar to ‘arachidonic acid’) – ’20 carbon units’ in length)
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(‘eicosanoids’ are a ‘subcategory’ of ‘oxylipins’)
(ie – ‘oxidized fatty acids’ of diverse ‘carbon units’ in length), and are distinguished from other ‘oxylipins’ by their overwhelming importance as ‘cell signaling molecules’)
(‘eicosanoids’ function in diverse ‘physiological systems’ and ‘pathological processes’ such as…)
(‘mounting’ or ‘inhibiting’ (‘inflammation’ / ‘allergy’ / ‘fever’ and other ‘immune responses’))
(‘regulating’ the ‘abortion’ of ‘pregnancy’ and ‘normal childbirth’)
(contributing to the ‘perception’ of ‘pain’)
(regulating ‘cell growth’)
(controlling ‘blood pressure’)
(modulating the ‘regional flow’ of ‘blood’ to ’tissues’)
(in performing these roles, ‘eicosanoids’ most often act as ‘autocrine signaling agents’ to impact their ‘cells of origin’ or as ‘paracrine signaling agents’ to ‘impact cells’ in the proximity of their ‘cells of origin’)
(‘eicosanoids’ may also act as ‘endocrine agents’ to control the function of ‘distant cells’)
(there are multiple subfamilies of ‘eicosanoids’, including most prominently…)
‘prostaglandins’
‘thromboxanes’
‘leukotrienes’
‘lipoxins’
‘resolvins’
‘eoxins’
(for each ‘subfamily’, there is the potential to have…)
*at least 4 separate series of ‘metabolites’*
*2 series derived from ω-6 PUFAs*
(‘arachidonic’ and ‘dihomo-gamma-linolenic’ acids)
*1 series derived from the ω-3 PUFA (eicosapentaenoic acid)*
*1 series derived from the ω-9 PUFA (‘mead acid’)*
(this ‘subfamily distinction’ is important)
(‘mammals’ (including humans) are unable to convert ω-6 into ω-3 PUFA)
(in consequence, ’tissue levels’ of the ω-6 and ω-3 PUFAs and their corresponding ‘eicosanoid metabolites’ link directly to the amount of ‘dietary ω-6 versus ω-3 PUFAs’ consumed)
(since certain of the ω-6 and ω-3 PUFA series of ‘metabolites’ have almost diametrically opposing physiological and pathological activities, it has often been suggested that the ‘deleterious consequences’ associated with the consumption of ‘ω-6 PUFA-rich diets’ reflects excessive production and activities of ω-6 PUFA-derived eicosanoids while the ‘beneficial effects’ associated with the consumption of ω-3 PUFA-rich diets reflect the excessive production and activities of ω-3 PUFA-derived eicosanoids)
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(in this view, the opposing effects of ω-6 PUFA-derived and ω-3 PUFA-derived ‘eicosanoids’ on ‘key target cells’ underlie the ‘detrimental’ and ‘beneficial effects’ of ω-6 and ω-3 PUFA-rich diets on…)
“‘inflammation’ and ‘allergy’ reactions”
‘atherosclerosis’
‘hypertension’
‘cancer growth’
(and a host of other ‘processes’)
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*🌈✨ *TABLE OF CONTENTS* ✨🌷*
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🔥🔥🔥🔥🔥🔥*we won the war* 🔥🔥🔥🔥🔥🔥