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-as of [8 APRIL 2024]–
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“STAT”
(as in “statistics”)
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*BRANDS* –>
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*aka HMG-CoA reductase inhibitors*
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-‘statins’ are a class of ‘lipid-lowering medications’ that reduce ‘illness/mortality’ in those who are at ‘high risk’ of ‘cardio-vascular disease’-
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(they are the most common cholesterol-lowering drugs)
Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and coronary heart disease via the mechanisms described by the lipid hypothesis.
Statins are effective in lowering LDL cholesterol and so are widely used for primary prevention in people at high risk of cardiovascular disease, as well as in secondary prevention for those who have developed cardiovascular disease.
Side effects of statins include muscle pain, increased risk of diabetes mellitus, and abnormal blood levels of liver enzymes.
Additionally, they have rare but severe adverse effects, particularly muscle damage.
They inhibit the enzyme HMG-CoA reductase which plays a central role in the production of cholesterol.
High cholesterol levels have been associated with cardiovascular disease.
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There are various forms of statins, some of which include
atorvastatin,
fluvastatin,
lovastatin,
pitavastatin,
pravastatin,
rosuvastatin,
and simvastatin.
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Several combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available.
Simvastatin is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system.
In 2005, sales were estimated at US$18.7 billion in the United States.
The best-selling statin is atorvastatin, also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history.
The manufacturer Pfizer reported sales of US$12.4 billion in 2008.
(due to patent expirations, several statins became available in 2016 as less expensive generics)
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*👨🔬🕵️♀️🙇♀️*SKETCHES*🙇♂️👩🔬🕵️♂️*
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💕💝💖💓🖤💙🖤💙🖤💙🖤❤️💚💛🧡❣️💞💔💘❣️🧡💛💚❤️🖤💜🖤💙🖤💙🖤💗💖💝💘
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*🌈✨ *TABLE OF CONTENTS* ✨🌷*
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🔥🔥🔥🔥🔥🔥*we won the war* 🔥🔥🔥🔥🔥🔥