-DXM-

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-as of [29 JUNE 2024]

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“dex tro meth OR fan”
(5 syllables)

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*MODUS OPERANDI*

*DXM JOURNALS*

*THE DXM SUB-REDDIT*

*NMDA*

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“dextromethorphan hydrobromide salt”

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*DXM / DM*

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-[dextro-methorphan] is a [drug] of the [morphinan class] with [β€˜sedative’ / ‘dissociative’ / ‘stimulant’] properties (at higher doses)-

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[it is a ‘cough suppressant’ in many over-the-counter cold and cough medicines including ‘generic labels’ + ‘store brands’…]

‘benylin DM’

‘mucinex DM’

‘camydex-20 tablets’

‘robitussin’

‘NyQuil’

‘dimetapp’

‘vicks’

‘coricidin’

‘delsym’

‘TheraFlu’

‘cheracol D’

(…and others…)

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(‘dextromethorphan’ has also found numerous other uses in ‘medicine’, ranging from…) 

‘pain relief’ 
(as either the ‘primary analgesic’ or an ‘opioid potentiator’)

TO

(‘psychological applications’ in treatment of ‘addiction’)

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(it is sold in a variety of ‘forms’…) 

‘syrup’

‘tablet’

‘spray’

‘lozenge’

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(in its pure form, ‘dextromethorphan’ occurs as a ‘white powder’)

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(DXM is also used recreationally)

(when exceeding label-specified maximum dosages, ‘dextromethorphan’ acts as a ‘dissociative anesthetic’)

(its ‘mechanism of action’ is via multiple effects, including actions as a ‘non-selective serotonin re-uptake inhibitor’ + a ‘sigma-1 receptor agonist’)

(DXM – and its major metabolite ‘dextrorphan’ – also act as an ‘NMDA receptor antagonist’ at high doses, which produces effects similar to (yet distinct from) the ‘dissociative states’ created by other dissociative anesthetics such as ‘ketamine’ + ‘phencyclidine’)

(further, the metabolite 3-methoxymorphinan also metabolizes into 3-hydroxymorphinan which has the potent ‘neuro-protective’ + ‘neuro-trophic’ effects of dextrorphan (thus a 2nd-level metabolite of DXM) produces ‘local anesthetic effects’ in ‘rats’ with potency above ‘dextrorphan’, but below that of DXM)

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