-as of [28 MAY 2025]-
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-SAVE [SPOT JAR]-
-REMOVE [LABEL] FROM [SPOT JAR]-
(PLACE IN DESIGNATED [ZIPLOC BAG]-
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(used as a sleep aid during my college years)
(the only non-prescription legal alternative i had at the time)
(recommended by el madre)
(1 pill = 25mg)
can be safely mixed w/ clonazepam
(but not supposed to mix with alcohol)
(it seems to enhance the effects of nicotine)
(there is a pleasant hangover effect)
(a cigarette will revive the effects of the DPH the next day)
(if only temporarily)
(maximum recommended dose is 50mg of the ‘hydro-chloride salt’)
potent anti-cholinergic agent
(which results in ‘dry mouth’)
“benadryl”
(brand name)
diphenhydramine hydrochloride
(as in “dissolved in hydrochloride salt”)
(allergy medication)
(first-generation antihistamine)
(deliriant)
(discovered in 1943 by ‘george rieveschl’)
(in 1946 it became the first prescription antihistamine approved by the US FDA)
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(“the benadryl drop”)
(can you feel it?)
(then GO FOR IT!)
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(in college, i started stocking up on OTC sleep aids (mostly benadryl) to take the night before exams + performances)
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*JANUARY 2014*
i forgot that i can’t buy benadryl on the EBT card…
john the drunk has a contrasting opinion on everything…
“take nyquil not benadryl”
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*FEBRUARY 2014*
i managed to get some benadryl off cheryl
(i should never have mentioned the robitussin to her)
time to take down 12 benadryl tablets
one more 48-pack of benadryl
finished off the cigarettes and benadryl
my vision is blurry from the benadryl
16 tabs of benadryl
cheryl is worried about me
(overdosing on benadryl?)
(the ‘right connecting point’ on my ‘lips’ stings)
(from ‘dry mouth’ associated with ‘dhp usage’?)
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*14 JUNE 2015*
downed 16 benadryl liquigels on saturday night / sunday morning…
combatting a bat with depression…
i had bought two 24-packs for john on friday night…
i have the relaxing morning-after effects now…
how do they mix with tussin?
(my tolerance is building)
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*16 SEPTEMBER 2015*
took down twenty-four 25mg capsules (600mg) over the course of the day…
gave me a pleasant buzz throughout the day…
and i feel great now…
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*21 SEPTEMBER 2015*
(took a 600mg dose today)
(24 pink pills)
(first it made me horny / cranky / unproductive)
(until i added a monster + cigarette to the mix)
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*22 SEPTEMBER 2015*
(taking another 600mg dose)
(should i risk going any higher?)
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*5 DECEMBER 2020*
(less than 600mg in the early morning)
(just dropped another 300mg @ 11:11AM)
(~36 25mg rite-aid pills)
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*28 SEPTEMBER 2021*
4:20PM
(my third dose of the day)
(12 pills)
(300mg)
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*22 JULY 2022*
500mg
(20 25mg pills)
2:12PM
(i’m starting to become immune to the effects of DPH)
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*31 DECEMBER 2022*
3:06AM
-24 25mg pills-
(standard 600mg dose)
(i have a cold)
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The cooling sensation from diphenhydramine mimics menthol’s effect because both substances act on the same nerve receptors, specifically the transient receptor potential melastatin-8 (TRPM8).
While the two compounds achieve their cooling effects through different mechanisms, both influence the way nerves perceive temperature.
Shared mechanism:
Activating TRPM8 receptors
Menthol is a chemical agonist of the TRPM8 receptor, directly activating it to create a cooling sensation.
This does not actually lower the temperature of the skin or throat but tricks the sensory neurons into sending a signal to the brain that registers as cold.
Diphenhydramine is primarily a sodium channel blocker with local anesthetic properties.
While menthol activates the TRPM8 receptor, diphenhydramine affects nerve signals by blocking sodium channels.
This anesthetic effect on nerve endings, including those with TRPM8 receptors, interferes with normal signal transmission.
The disruption can be perceived as a cool or numbing sensation, similar to how menthol “fools” the cold receptors.
Distinct but complementary effects on the throat
In addition to their shared effect on temperature-sensing nerves, diphenhydramine has other properties that contribute to the unique “cool and tight” feeling in the throat
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Anticholinergic effects:
Diphenhydramine is a potent anticholinergic agent, meaning it blocks the action of acetylcholine.
This causes the drying of mucous membranes, which is why diphenhydramine is used in some cold medications to “dry up” a runny nose.
The resulting dry mouth and throat can feel like a “tightness” or contraction
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Anesthetic properties:
Diphenhydramine’s ability to act as a local anesthetic by blocking sodium channels can also contribute to the perception of a cool, numb sensation in the throat
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Why the feeling is often described as tight
The combination of these effects explains the complete sensation:
The cooling effect is caused by a TRPM8-mediated sensory trick, similar to menthol.
The “tight” sensation is caused by the drying of tissues in the throat due to the drug’s anticholinergic properties.
This blend of cold sensation and physical dryness and numbness results in the characteristic “cool, tight” feeling that is sometimes compared to menthol
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👈👈👈☜*“DIPHEN-HYDRAMINE”* ☞ 👉👉👉
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💕💝💖💓🖤💙🖤💙🖤💙🖤❤️💚💛🧡❣️💞💔💘❣️🧡💛💚❤️🖤💜🖤💙🖤💙🖤💗💖💝💘
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*🌈✨ *TABLE OF CONTENTS* ✨🌷*
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🔥🔥🔥🔥🔥🔥*we won the war* 🔥🔥🔥🔥🔥🔥