*’x-linked dominant dis-orders’ are caused by ‘mutations’ in ‘genes’ on the ‘X chromosome’*
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(only a few disorders have this inheritance pattern, with a prime example being ‘X-linked hypophosphatemic rickets’)
Males and females are both affected in these disorders, with males typically being more severely affected than females.
Some X-linked dominant conditions, such as Rett syndrome, incontinentia pigmenti type 2, and Aicardi syndrome, are usually fatal in males either in utero or shortly after birth, and are therefore predominantly seen in females.
Exceptions to this finding are extremely rare cases in which boys with Klinefelter syndrome (47,XXY) also inherit an X-linked dominant condition and exhibit symptoms more similar to those of a female in terms of disease severity.
The chance of passing on an X-linked dominant disorder differs between men and women.
The sons of a man with an X-linked dominant disorder will all be unaffected (since they receive their father’s Y chromosome), and his daughters will all inherit the condition.
(a woman with an X-linked dominant disorder has a 50% chance of having an affected fetus with each pregnancy, although it should be noted that in cases such as incontinentia pigmenti, only female offspring are generally viable)
(in addition, although these conditions do not alter fertility per se, individuals with “rett syndrome” or “aicardi” syndrome rarely reproduce)
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*🌈✨ *TABLE OF CONTENTS* ✨🌷*
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🔥🔥🔥🔥🔥🔥*we won the war* 🔥🔥🔥🔥🔥🔥