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α-Amino-3-hydroxy-5-Methyl-4-isoxazolePropionic Acid
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better known as AMPA
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter ‘glutamate’
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There are several types of glutamatergic ion channels in the central nervous system including
AMPA channel
kainic acid channel
N-methyl-D-aspartic acid (NMDA) channel
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In the synapse, these receptors serve very different purposes.
AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.[2]
AMPA generates fast excitatory postsynaptic potentials (EPSP).[1]
AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV.
AMPA was first synthesized, along with several other ibotenic acid derivatives, by Krogsgaard-Larsen, Honoré, and others toward differentiating glutamate sensitive receptors from aspartate sensitive receptors
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See also[edit]
Ampakine
References[edit]
^ Jump up to: a b Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.
^ Dinh, L; Nguyen T; Salgado H; Atzori M (2009). “Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat”. Neurochem Res. 34 (11): 1896–906. doi:10.1007/s11064-009-9966-z. PMID 19357950. S2CID 25255160.
^ Krogsgaard-Larsen, P; Honore T; Hansen JJ; Curtis DR; Lodge D (1980). “New class of glutamate agonist structurally related to ibotenic acid”. Nature. 284 (5751): 64–66. doi:10.1038/284064a0. PMID 6101908. S2CID 4252428.
en.wikipedia.org /wiki/AMPA
AMPA
Contributors to Wikimedia projects3-3 minutes 11/21/2003
DOI: 10.1007/s11064-009-9966-z, Show Details
AMPA
AMPA.svg
Names
IUPAC name
2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
Identifiers
CAS Number
74341-63-2 ☒
3D model (JSmol)
Interactive image
ChEMBL
ChEMBL276815 ☒
ChemSpider
1184 check
DrugBank
DB02057 check
IUPHAR/BPS
4131
MeSH AMPA
PubChem CID
1221
CompTox Dashboard (EPA)
DTXSID20868301 Edit this at Wikidata
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InChI
show
SMILES
Properties
Chemical formula
C7H10N2O4
Molar mass 186.167 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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