“ven la FAX ine”
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EFFEXOR
venlafaxine — brand names: Effexor, Effexor XR, Lanvexin, and Trevilor — is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. this means it increases the concentrations of the neurotransmitters serotonin and norepinephrine in the body and the brain. first introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder (MDD),generalised anxiety disorder (GAD), panic disorder and social phobia.
comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis has shown venlafaxine, alongside mirtazapine, escitalopram and sertraline were significantly more efficacious. remission rates (defined as a HAM-D score of 7 or less) were 58% for venlafaxine plus mirtazapine. this combination is known by the medical slang term “California rocket fuel”.
the rate of life-threatening or lethal outcomes for suicidal overdoses of venlafaxine is lower than for the TCAs, MAOIs and bupropion and comparable to several of the SSRIs. it is metabolised in the body into another antidepressant drug called desvenlafaxine (O-desmethylvenlafaxine) which is also sold as an antidepressant, under the brand name Pristiq.
both venlafaxine and paroxetine have been linked to the most severe discontinuation symptoms.
in combination with an antipsychotic medicine aripiprazole, better results in treatment of hard-to-treat depression in older adults have been demonstrated.
in 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions.
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